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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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PREVALENCE OF BONE DISEASE IN CHILDREN AND ADOLESCENTS WITH SICKLE CELL ANEMIA: SINGLE INSTITUTE EXPERIENCE IN KINGDOM OF SAUDI ARABIA PREVALENCE OF BONE DISEASE IN CHILDREN AND ADOLESCENTS WITH SICKLE CELL ANEMIA: SINGLE INSTITUTE EXPERIENCE IN KINGDOM OF SAUDI ARABIA |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Background. Bone disease is an increasingly recognized serious cause of morbidity on young adults with hemoglonopathies disorders. Sickle cell anemia (SCA) is a prevalent genetic disorder in Saudi Arabia. Sickle hemoglobin leads to tissue hypoxia and adverse effect on bone, sickler has multiple bone problems include, bone pain participate vaso-occlusive crises, osteomalacia, osteopenia, spinal deformations, fractures, severe osteoporosis and a vascular necrosis. Aims. To assess the prevalence of bone disease among children with sickle cell anemia at our institute. Methods. Two hundred three (203) SCA patients were enrolled in the study, age ranges from 1-18 years old. (98 females & 105 males). These patient were treated and followed at King Abdulaziz University Hospital (KAUH), Jeddah Kingdom of Saudi Arabia (KSA). All patients were assessed clinically. Blood and urine samples were obtained for the determination of biochemical and hormonal profiles, included , PTH, 25 OH vitamin D3. Bone maturation was assessed by radiological bone age. Bone mineral density (BMD) by DEXA was determined on half of the adolescent patients. Bone formation markers (bone-specific alkaline phosphatase and osteocalcin) and bone resorption markers (Pyridinoline and deoxy pyridinoline) were analysed for patients whom had BMD and referred for treatment. Results. High prevalence of hypovitamnosis D, 25% in sickle cell children patients, 55% among adolescents. High prevalence of reduced low bone mass (LBM) among adolescents whom screened. Summary. Bone assessment was found to be suboptimal in children and adolescents in our institute. All sickles should be screened annually for bone disease. Calcium and vitamin D deficiencies may further compound the patients risk for bone disease. Early diagnosis and treatment can prevent a bone complications |
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ردمد |
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0390-6078 |
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اسم الدورية |
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Haematologica |
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المجلد |
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93 |
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العدد |
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519 |
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سنة النشر |
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1429 هـ
2008 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Sunday, August 30, 2009 |
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الباحثون
| سعاد الجاعوني | Al-Jaouni, Soad | باحث رئيسي | دكتوراه | |
| نادية فدا | Fida, Nadia | باحث مشارك | دكتوراه | |
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