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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Bioactive C15 acetogenins from the red alga Laurencia obtusa Bioactive C15 acetogenins from the red alga Laurencia obtusa |
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الموضوع |
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كيمياء |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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The petroleum ether extract of the red alga Laurencia obtusa afforded three new C15 acetogenins (cyclic ether enyne): (12Z)-cis-maneonene-D (1), (12E)-cis-maneonene-E (2), and (12Z)-trans-maneonene-C (3), along with one known cis-maneonene-A (4). Blood neutrophils were prepared, cultured, and incubated for 24, 48, and 72 h in medium with and without isolated compounds. Blood neutrophils were prepared, cultured, and incubated for 24, 48 and 72 h in medium with and without the isolated compounds. Both morphology and DNA fragmentation methods assessed the percentage of neutrophils apoptosis in each culture. In the present study, several observations have been made concerning the apoptosis-inducing or inhibiting effect of 1 and 2. Both compounds had no inhibition of apoptosis but apoptosis was enhanced significantly by aging. However, 1 stimulated apoptosis of normal only at the initial 24 h. After that there was no significant difference in apoptosis with or without compound 1, while 2 stimulated apoptosis at all the times. The apoptosis induced by these two compounds was demonstrated by DNA fragmentation assay and microscopic observation. These observations suggest that compounds 1 and 2 may be involved in regulation of programmed death in the initiation and propagation of inflammatory responses. |
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ردمد |
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0009-2363 |
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اسم الدورية |
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Chemical and Pharmaceutical Bulletin |
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المجلد |
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59 |
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العدد |
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10 |
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سنة النشر |
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1432 هـ
2011 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Sunday, December 4, 2011 |
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الباحثون
| سيف الدين نصر عياد | Ayyad, Seif-Eldin N | باحث | دكتوراه | snayyad2@yahoo.com |
| خالد عمر الفوتي | Al-Footy, Khalid Omar | باحث | دكتوراه | kalfooti@kau.edu.sa |
| وليد محمد العارف | Alarif, Walied Mohamed | باحث | دكتوراه | welaref@kau.edu.sa |
| طارق رشاد سبحي | Sobahi, Tariq Rashad | باحث | دكتوراه | drtariq_s@hotmail.com |
| سالم أحمد باسيف | Basief, Salem A | باحث | دكتوراه | sbasaif@yahoo.com |
| محمد صالح مكي | Makki, Mohamed S | باحث | دكتوراه | |
| عبدالله محمد عسيري | Asiri, Abdullah Mohamed | باحث | دكتوراه | aasiri2@kau.edu.sa |
| أمين يحيى الحلواني | Al Halawani, Amani Yahya | باحث | دكتوراه | |
| A F Badria | Badria, A F | باحث | دكتوراه | |
| F A. A. R. Badria | Badria, F A. A. R. | باحث | دكتوراه | |
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