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Center of Excellence for Advanced Materials Research
Document Details
Document Type
:
Article In Journal
Document Title
:
Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents
Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents
Subject
:
Chemistry
Document Language
:
English
Abstract
:
We have investigated the antibacterial activity of some new steroidal thiosemicarbazones and their Pd(II) metal complexes were prepared by the reaction of the thiosemicarbazones with [Pd(DMSO) 2Cl 2]. The steroidal thiosemicarbazones were prepared by the reaction of thiosemicarbazides with a steroidal ketone. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, FAB mass spectroscopic methods, elemental analyses and TGA analysis. The antibacterial activity of these compounds were tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The results showed that steroidal complexes are better inhibitors of both types of the bacteria (Gram-positive and Gram-negative) as compared to steroidal thiosemicarbazones. Compound Ia displays remarkable antibacterial activity as compared to amoxicillin.
ISSN
:
1420-3049
Journal Name
:
Molecules
Volume
:
15
Issue Number
:
7
Publishing Year
:
1431 AH
2010 AD
Article Type
:
Article
Added Date
:
Saturday, February 18, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
عبدالله محمد عسيري
Asiri, Abdullah Mohamed
Researcher
Doctorate
aasiri2@kau.edu.sa
سلمان أحمد خان
Khan, Salman A
Researcher
Doctorate
sahmad_phd@yahoo.co.in
Files
File Name
Type
Description
32335.pdf
pdf
Abstract
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