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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Microarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma
Microarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma
 
لغة الوثيقة : الانجليزية 
المستخلص : Brain metastatic papillary thyroid carcinomas (PTCs) are afflicted with unfavorable prognosis; however, the underlying molecular genetics of these rare metastases are virtually unknown. In this study, we compared whole transcript microarray expression profiles of a BRAF mutant, brain metastasis from a PTC, including its technical replicate (TR), with eight non-brain metastatic PTCs and eight primary brain tumors. The top 95 probe sets (false discovery rate (FDR) p-value < 0.05 and fold change (FC) > 2) that were differentially expressed between the brain metastatic PTC, including the TR, and both, non-brain metastatic PTCs and primary brain tumors were in the vast majority upregulated and comprise, e.g. ROS1, MYBPH, SLC18A3, HP, SAA2-SAA4, CP, CCL20, GFAP, RNU1-120P, DMBT1, XDH, CXCL1, PI3, and NAPSA. Cytokines were represented by 10 members in the top 95 probe sets. Pathway and network analysis (p-value < 0.05 and FC > 2) identified granulocytes adhesion and diapedesis as top canonical pathway. Most significant upstream regulators were lipopolysaccharide, TNF, NKkB (complex), IL1A, and CSF2. Top networks categorized under diseases & functions were entitled migration of cells, cell movement, cell survival, apoptosis, and proliferation of cells. Probe sets that were significantly shared between the brain metastatic PTC, the TR, and primary brain tumors include CASP1, CASP4, C1R, CC2D2B, RNY1P16, WDR72, LRRC2, ZHX2, CITED1, and the noncoding transcript AK128523. Taken together, this study identified a set of candidate genes and biofunctions implicated in, so far nearly uncharacterized, molecular processes of a brain metastasis from a PTC. 
ردمد : 5088-2820 
اسم الدورية : American journal of cancer research 
المجلد : 6 
العدد : 10 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Wednesday, July 12, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Hans-Juergen SchultenSchulten, Hans-Juergen باحثدكتوراه 
Deema HusseinHussein, Deema باحثدكتوراه 
Fatima Al-AdwaniAl-Adwani, Fatima باحثدكتوراه 
Sajjad KarimKarim, Sajjad باحثدكتوراه 
Jaudah Al-MaghrabiAl-Maghrabi, Jaudah باحثدكتوراه 
Mona Al-SharifAl-Sharif, Mona باحثدكتوراه 
Awatif JamalJamal, Awatif باحثدكتوراه 
Sherin BakhashabBakhashab, Sherin باحثدكتوراه 
Jolanta WeaverWeaver, Jolanta باحثدكتوراه 
Fahad Al-GhamdiAl-Ghamdi, Fahad باحثدكتوراه 
Saleh S BaeesaBaeesa, Saleh Sباحثدكتوراه 
Mohammed BangashBangash, Mohammed باحثدكتوراه 
Adeel ChaudharyChaudhary, Adeel باحثدكتوراه 
Mohammed Al-QahtaniAl-Qahtani, Mohammed باحثدكتوراه 

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اسم الملفالنوعالوصف
 41978.pdf pdf 

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