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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients:in neutrophils from diabetic patients: association with periodontitis
Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients:in neutrophils from diabetic patients: association with periodontitis
 
لغة الوثيقة : الانجليزية 
المستخلص : Inflammation and oxidative stress are important factors in the pathogenesis of diabetes and contribute to the pathogenesis of diabetic complications. Periodontitis is an inflammatory disease that is characterized by increased oxidative stress, and the risk for periodontitis is increased significantly in diabetic subjects. In this study, we examined the superoxide (02 -)-generating reduced nicotinamide adenine dinucleotide phosphate - oxidase complex and protein kinase C (PKC) activity in neutrophils. Fifty diabetic patients were grouped according to glycemic control and the severity of periodontitis. Neutrophils from diabetic patients with moderate [amount of glycated hemoglobin (HbA1c) between 7.0% and 8.0%] or poor (HbA1c >8.0%) glycemic control released significantly more O2- than neutrophils from diabetic patients with good glycemic con trol (HbA1c <7.0%) and neutrophils from nondiabetic, healthy individuals upon stimulation with 4pphorbol 12-myristate 13-acetate or N-formyl-MetLeu-Phe. Depending on glycemic status, neutrophils from these patients also exhibited increased activity of the soluble - and membrane-bound forms of PKC , elevated amounts of diglyceride, and enhanced phosphorylation of p4 7 -phox during cell stimulation. In addition, we report a significant correlation between glycemic control (HbA1c levels) and the severity of periodontitis in diabetic patients, suggesting that en hanced oxidative stress and increased inflanunation exacerbate both diseases. Thus, hyperglycemia can lead to a novel form of neutrophil priming, where elevated PKC activity results in increased phosphorylation ofp47-phox and O2- release.]. Leukoc. Biol. 78: 862-870; 2005. 
ردمد : 1 
اسم الدورية : مجلة علم الأحياء 
المجلد : 87 
العدد : 1 
سنة النشر : 2005 هـ
2005 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, May 20, 2008 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
ممدوح كريمهKarima, Mamdouh باحث رئيسيدكتوراهmkarimah@kau.edu.sa

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